| 五氯酚钠对梨形环棱螺毒理效应的研究 |
| Studies on Toxicological Effect of Sodium Pentachlorophenol on Bellamya purificata |
| 投稿时间：2012-06-25 修订日期：2012-07-17 |
| DOI： |
| 中文关键词:五氯酚钠 梨形环棱螺 急性毒性实验 毒理效应 精氨酸激酶 |
| 英文关键词:Sodium pentachlorophenol Bellamya purificata Acute toxicity test Toxicological effect Arginine kinase |
| 基金项目:湖北省教育厅2010年度重点项目（No. D20102505），中国水产科学研究院淡水生态与健康养殖重点开放实验室项目(No. 2007FEA0205），中国水产科学研究院内陆渔业生态环境和资源重点开放实验室项目（No. YM2007－03），湖北师范学院2008年度人才项目(No.2008F14) |
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| 中文摘要: |
| 采用在体暴露实验的方法，研究了不同浓度五氯酚钠（Na-PCP）在不同暴露时间（24、48、72、96h）下对梨形环棱螺的急性毒性以及五氯酚钠对肝脏、鳃和腹足中精氨酸激酶（AK）活性的影响。结果显示，Na-PCP对梨形环形螺的半致死浓度为0.411mg•L-1,安全浓度为0.0411mg•L-1；Na-PCP暴露下，梨形环棱螺肝脏中单位蛋白AK活性在低浓度下被诱导增长，而在高浓度下则出现被抑制的现象；鳃、腹足中单位蛋白AK活性伴随Na-PCP浓度的增加而下降，表现出时间剂量上被抑制，但腹足中下降幅度相对鳃中较大。结果显示，AK可以作为指示五氯酚钠对梨形环棱螺毒理效应的生物标志物。 |
| 英文摘要: |
| An exposure experiment in vivo was carried out to study the acute toxicity of Sodium pentachlorophenol(Na-PCP) on Bellamya purificata and its effects on level of arginine kinase(AK) in liver, gill and gastropoda of B. purificata at different concentrations and exposure times(24，48，72 and 96 h).The results showed that the LC50 values of Na-PCP on B. purificata was 0.411 mg/L，and the safe concentration was 0. 0411 mg/L; the activity of AK in liver of B. purificata was induced at low concentrations while inhibited at high concentrations，while the activities of AK in gill and gastropoda decreased as the concentration of Na-PCP increasing，which showed a significant time-dosage inhibited effect，and the activity of AK in gastropoda decreased more drastically than that of gill at the same time. The results suggested that AK were sensitive to the exposure of Na-PCP and could be used as a biomarker to evaluate the aquatic environment Na-PCP pollution. |
| 王元川,侯建军,陈亚琼,舒晓,夏晓芬.2012.五氯酚钠对梨形环棱螺毒理效应的研究[J].水生态学杂志,33(4):118-123. |
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