| 鱼类MHCⅡ类基因与免疫抗性的研究进展 |
| Advance of MHC ClassⅡ Genes Associated with Immunity and Disease Resistance in Fish |
| 投稿时间：2009-12-24 修订日期：2010-03-15 |
| DOI： |
| 中文关键词:主要组织相容性复合体 鱼类 多态 抗病力 |
| 英文关键词:MHC Fish Polymorphism Disease resistance |
| 基金项目:国家自然科学基金（３０９７２２５１；３１０７２２０５）；广东省自然科学基金（７０１０４２３）。 |
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| 中文摘要: |
| 主要组织相容性复合体（ＭＨＣ）与免疫应答和疾病抗性密切相关，对其免疫遗传机制的深入探讨是多年来的研究热点。随着分子生物学的发展，从遗传选育角度提高鱼类对病原的抗性，开展抗病育种具有治本的功效。就鱼类ＭＨＣⅡ类基因的表达调控和多态性研究与细菌性疾病、病毒性疾病和寄生虫的关联分析加以阐述，为今后进一步探讨ＭＨＣ基因与鱼类抗病育种等提供了参考。 |
| 英文摘要: |
| The major histocompatibility complex are closely associated with the immune response and disease resistance，and a series of study had been focused on revealing the immunogenetic mechanisms in fish for many years. Accompanying the development of molecular biology，disease-resistant breeding will be a permanent effect to improve fish's resistance to pathogens by means of animal genetics and breeding . The association of MHC class Ⅱ expression，regulation and polymorphism with bacterial ,virus and parasite were particularly reviewed in this paper, which could provide insight for the further research on the breeding for disease resistance.
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| 赵红娟,李 华,于辉,王继文.2010.鱼类MHCⅡ类基因与免疫抗性的研究进展[J].水生态学杂志,31(5):111-115. |
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