| 氟苯尼考在大黄鱼体内的药动学及组织分布研究 |
| Pharmacokinetics and Tissue Distribution of florfenicol in large yellow croakers,Pseudosciaena crocea |
| 投稿时间：2009-05-10 修订日期：2009-06-13 |
| DOI： |
| 中文关键词:氟苯尼考 大黄鱼 药代动力学 组织分布 |
| 英文关键词:florphenicol Pseudosciaena crocea pharmacokinetics tissue distribution |
| 基金项目: |
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| 中文摘要: |
| 在试验水温（25±1）℃时，按20mg/kg剂量给大黄鱼单次口灌氟苯尼考后，采用高效液相色谱法测定了血浆、肌肉、肝脏和肾脏各组织中的药物浓度，并对其进行了药代动力学及组织分布特征的研究。结果表明，大黄鱼血浆中氟苯尼考的药时数据可用一级吸收一室开放模型来描述，其药动学方程为：C血液=43.365 (e-0.047t－e-0.266t)，而肌肉、肝脏和肾脏各组织均符合一级吸收二室开放模型，其药动学方程分别为：C肌肉= 2.216e―1.732t＋0.093e－0.007t－2.309e－2.212t、C肝脏= 48.913e―6.334t＋0.773e－0.022t－49.686e－30.928t、C肾脏= 14.709e―1.558t＋0.167e－0.010t－14.876e－1.880t。大黄鱼对氟苯尼考的代谢与分布具有明显的组织特异性，肌肉中的药物浓度低于同期其他组织。肌肉作为鱼类最主要的可食性组织，建议将其作为该药残留监控的靶组织，相应的休药期至少为４d。 |
| 英文摘要: |
| In order to study the pharmacokinetics and tissue distribution of florphenicol in Pseudosciaena crocea, the concentrations of florfenicol were determined in plasma, muscle, liver, kidney of Pseudosciaena crocea following oral administration in a single dose of 20 mg/kg at (25±1)℃ by using high performance liquid chromatography (HPLC).The results showed that the plasma concentration-time data of florfenicol were best described by one-compartment open model with first-order absorb, described with C＝43.365 (e-0.047t－e-0.266t), whereas the concentration-time data of other tissues were all described by two-compartment open model with first-order absorb, described with C = 2.216e―1.732t＋0.093e－0.007t－2.309e－2.212t、C = 48.913e―6.334t＋0.773e－0.022t－49.686e－30.928t and C = 14.709e―1.558t＋0.167e－0.010t－14.876e－1.880t ,respectively. The metabolism and distribution of florfenicol in Pseudosciaena crocea exhibited an apparent tissue-specificity. Level of florfenicol in muscle was under the corresponding concentration of other tissues. As a main edible tissue, muscle was selected as target tissue in this experiment. According to the maximum residue limit (MRL) of 0.1mg/kg in muscle, the withdrawal period should not be less than 4d under this experiment condition. |
| 秦方锦 ,金珊,邢晨光,王国良.2010.氟苯尼考在大黄鱼体内的药动学及组织分布研究[J].水生态学杂志,31(1):102-106. |
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